Group I ribozymes are an ancient class of RNA catalysts that serve as a paradigm for the self-assembly of complex structures of non-coding RNA. The diversity of subtypes illustrates the modular character of RNA architecture and the potential for the evolution of new functions. The folding mechanisms of group I ribozymes illustrate the hierarchy of folding transitions and the importance of kinetic partitioning among competing folding pathways. Studies on group I splicing factors demonstrate how proteins facilitate the assembly of splicing complexes by stabilizing tertiary interactions between domains and by ATP-dependent cycles of RNA unfolding.
CITATION STYLE
Woodson, S. A., & Chauhan, S. (2008). Group I Ribozymes as a Paradigm for RNA Folding and Evolution. In Non-Protein Coding RNAs (pp. 145–166). Springer Berlin Heidelberg. https://doi.org/10.1007/978-3-540-70840-7_7
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