Enhancing the Solubility of Ketoconazole via Pharmaceutical Cocrystal

Abstract

This present research is to synthesized and characterized cocrystal of ketoconazole through cocrystallization process in order to improve solubility properties of ketoconazole. Ketoconazole cocrystal synthesized by the slurry method and characterized using diffractometry (Powder X-Ray Diffraction), Thermogram (Differential Scanning Calorimetry), Microscopy (Polarizing microscope), FTIR spectroscopy and solubility analysis were performed to evaluate the cocrystal. The PXRD diffractogram of cocrystal ketoconazole is different compared to pure component. New peaks characteristic of cocrystal appear at a 2θ value of 16.94° and 24.58° In addition, synthesized cocrystal have unique habit crystal, melting point and FTIR spectrum compared to single component. The ketoconazole cocrystal from slurry method showed an improved solubility by 50 times compared to ketoconazole. This study showed that cocrystallization between ketoconazole and ascorbic acid were successfully formed and enhanced the solubility of the drug.