Total lymphoid irradiation in rheumatoid arthritis: A ten-year followup

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Abstract

Objective. To report the findings of a 10-year followup of patients enrolled in a randomized trial of total lymphoid irradiation (TLI) versus chemotherapy for rheumatoid arthritis (RA). Methods. A retrospective analysis of the charts of 19 patients who had been included in a randomized trial comparing TLI and chemotherapy for the treatment of RA. Results. Ten years after the start of the trial, a higher number of TLI-treated patients had died (7 of 10), compared with patients who had received chemotherapy (2 of 9). In addition, 3 of the TLI-treated patients developed B cell-related malignancies, whereas no such malignancies developed in the control group. Conclusion. TLI was associated with a less-favorable long-term outcome than chemotherapy. These data stress the importance of careful long-term followup in experimental trials of immunosuppressive agents.

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Westhovens, R., Verwilghen, J. O., & Dequeker, J. D. J. (1997). Total lymphoid irradiation in rheumatoid arthritis: A ten-year followup. Arthritis and Rheumatism, 40(3), 426–429. https://doi.org/10.1002/art.1780400306

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