Rabbit cloning

Abstract

Rabbit somatic cell nuclear transfer (SCNT) offers new opportunities for basic research, biomedical and agricultural applications and genome preservation. However, the technology is still in a very early development stage and it is relatively inefficient proving many early expectations premature. The technical steps of SCNT are extremely complex. They are also very sensitive to small changes and fluctuations in technical parameters. Furthermore, the biological background of the reprogramming process is not fully understood. It makes it virtually impossible to optimize a protocol providing ideal recipient oocytes and donor cells for the process. In this chapter we will intend to summarize the current status of nuclear transfer technology in rabbits and to give the readers a brief insight of its future use. © 2009 Springer Netherlands.