Elongator protein 3 (Elp3) lysine acetyltransferase is a tail-anchored mitochondrial protein in toxoplasma gondii

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Abstract

Background: Protein acetylation is prevalent in mitochondria, yet acetyltransferases mediating this activity are unknown. Results: Toxoplasma Elongator protein 3 (Elp3) possesses a unique C-terminal transmembrane domain necessary and sufficient to target it to the mitochondria. Conclusion: Elp3 is an essential tail-anchored mitochondrial acetyltransferase in Toxoplasma. Significance: Elp3 has conserved functions involving mitochondria that may predate its established role in transcription. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.

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Stilger, K. L., & Sullivan, W. J. (2013). Elongator protein 3 (Elp3) lysine acetyltransferase is a tail-anchored mitochondrial protein in toxoplasma gondii. Journal of Biological Chemistry, 288(35), 25318–25329. https://doi.org/10.1074/jbc.M113.491373

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