Triiodoisocyanuric acid (TICA) was prepared in 90% yield by heating trichloroisocyanuric acid with iodine in a sealed tube. The reaction of TICA with activated arenes in acetonitrile led to an efficient and highly regioselective formation of the corresponding iodoarenes, in 73-93% isolated yield. Aniline and phenol are monoiodinated regioselectively using MeOH (53%) and CH2Cl2 (88%) as solvents, respectively. ©2008 Sociedade Brasileira de Química.
CITATION STYLE
Ribeiro, R. D. S., Esteves, P. M., & De Mattos, M. C. S. (2008). Triiodoisocyanuric acid: A new and convenient reagent for regioselective iodination of activated arenes. Journal of the Brazilian Chemical Society, 19(7), 1239–1243. https://doi.org/10.1590/S0103-50532008000700002
Mendeley helps you to discover research relevant for your work.