A 60's man was diagnosed as hepatocellula carcinoma at S4/8 and S6 in the liver. Because he suffered from poor control of diabetes mellitus (HbA1c was over 8% for long time), medication of di-peptidyl peptidase-IV (DPP-4) inhibitor was started preoperatively. Befere intaking the DPP-4 inhibitor, the size of tumor in dynamic CT was following; the tumor of S4/8 was 5.0 cm and that of S6 was 2.5 cm. Three weeks after starting medication, the tumor was shrinked respectively; the tumor of S4/8 was 2.5 cm and that of S6 was 2.0 cm. AFP and PIVKA-II were both significantly reduced. Histologically, large number of lymphocytes were infiltrated in a hepatocellular carcinoma, and the infiltrating lymphocytes were proved as CD8 positive T cell by immunohistochemistry staining. We report an extremely rare case of spontaneous regression of hepatocellular carcinoma that is strongly thought to associate with immunoresponse. © 2012 The Japan Society of Hepatology.
CITATION STYLE
Yamamotou, S., Tokuhara, T., Nishikawa, M., Nishizawa, S., Nishioka, T., Nozawa, A., … Kubo, S. (2012). Spontaneous regression of hepatocellular carcinoma after improving diabetes mellitus: Possibly responsible for immune system. Kanzo/Acta Hepatologica Japonica, 53(3), 164–174. https://doi.org/10.2957/kanzo.53.164
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