Modeling subtilin production in bacillus subtilis using stochastic hybrid systems

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Abstract

The genetic network regulating the biosynthesis of subtilin in Bacillus subtilis is modeled as a stochastic hybrid system. The continuous state of the hybrid system is the concentrations of subtilin and various regulating proteins, whose productions are controlled by switches in the genetic network that are in turn modeled as Markov chains. Some preliminary results are given by both analysis and simulations. © Springer-Verlag 2004.

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Hu, J., Wu, W. C., & Sastry, S. (2004). Modeling subtilin production in bacillus subtilis using stochastic hybrid systems. Lecture Notes in Computer Science (Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), 2993, 417–431. https://doi.org/10.1007/978-3-540-24743-2_28

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