Antipyretic Effect of Cinnamomum burmannii (Nees & T.Nees) Blume Infusion in Fever-induced Rat Models

Abstract

Background: Fever is a frequent clinical sign encountered in human especially in children. Unfortunately, access to health care and medications (antipyretics) are hampered by shortage of services and affordability, which are accentuated by local resources mainly for those living in remote areas. Therefore, using herbal medicineas an alternative in treating fever should be developed as substituent reliance on synthetic antipyretic. This study is conducted to observe antipyretic effect of Cinnamomum burmannii (Nees & T.Nees) Blume infusion using Diphtheria Tetanus Pertussis (DTP) vaccine-induced fever in rats.Methods: Twenty-eight male Wistar rats (150200 g) were randomly allocated into control and treatment groups. Fever was induced with DTP vaccine intramuscularly injected (0.7 mL/200 g body weight) and 4 hours later, distilled water (5 mL) was administered orally to the control group while the treatment group received 5 mL of 3%, 6%, and 12% of cinnamon infusion. Rectal temperature was measured before the pretreatment, 4 hours afterDTP vaccine-induced fever injection and at a 30-minute interval during 180 minutes after the infusion administration. All procedures and protocols were performed in October 2012 at the Pharmacology Laboratory, Faculty of Medicine, Universitas Padjadjaran, Bandung.Results: Data analysis using the one way analysis of variance (ANOVA) showed significant reduction (p<0.001) of rectal temperature after 30 minutes and Duncan Post-Hoc test showed significant effect for  6% and 12% of cinnamon infusion groups.Conclusion The antipyretic effect of 6% and 12% of Cinnamomum burmannii (Nees & T.Nees) Blume infusion in fever-induced rat models is found in the first 30 minutes.Key words: Antipyretic, Cinnamomum burmannii (Nees & T.Nees) Blume, fever, herbal medicine Efek Antipiretik Infusa Cinnamomum burmannii (Nees & T.Nees) Blume pada Tikus yang Diinduksi Demam AbstrakLatar belakang: Demam merupakan suatu gejala yang sering muncul terutama pada anak-anak. Antipiretik merupakan obat yang sering digunakan untuk meringankan demam, namun akses kepada pelayanan kesehatan dan pengobatan masih belum terjangkau bagi penduduk yang tinggal di daerah terpencil. Menggunakan herbal sebagai alternatif pengobatan demam harus dikembangkan sebagai substituen terhadap ketergantungan pada obat sintetik. Penelitian ini dilakukan dengan tujuan untuk mengetahui efek antipiretik infusa Cinnamomum burmannii (Nees & T.Nees) Blume pada tikus yang diinduksi dem…