Abstract
In this work we investigated the interaction between the short ac(4)a C-rich peptide nucleic acid (PNA) probe and two intramolecular G-quadruplex targets having the same G-tetrad core, but different folding topologies. The T(G(4)T)(3)G(4)T and the recently reported tetra-end-linked-(TG(4)T)(4) G-rich oligonucleotides (GROs) were chosen and synthesized for this study. UV, CD, and MS experiments revealed the formation of novel 1:1 G-quadruplex-PNA complexes besides the expected DNA-PNA heteroduplexes.
Cite
CITATION STYLE
Amato, J., Gabelica, V., Borbone, N., Rosu, F., De Pauw, E., Oliviero, G., … Mayol, L. (2008). A short C-rich PNA fragment capable to form novel G-quadruplex-PNA complexes. Nucleic Acids Symposium Series (2004), (52), 167–168. https://doi.org/10.1093/nass/nrn085
Register to see more suggestions
Mendeley helps you to discover research relevant for your work.
