Despite a tremendous amount of progress in the identification and characterization of many new players as components of class 3 secreted semaphorin signaling in growth cone steering (Fig. 1), our understanding of the molecular mechanisms is far from complete. More questions remain to be answered: how are differential cytoskeletal changes within a growth cone achieved in response to semaphorins? What are the target(s) of cydic nucleotide modulation? How does a growth cone make a reliable decision in response to a shallow gradient? And finally, how does a growth cone maintain its sensitivity to a decreasing concentration of semaphorins when it is growing away from the source? With a high degree of interest in the field with the development of novel technologies in analyzing growth cone steering, we expect to see a much more complete picture of semaphoring signaling in the near future. © 2007 Landes Bioscience and Springer Science+Business Media.
CITATION STYLE
Shim, S., & Ming, G. L. (2007). Signaling of secreted semaphorins in growth cone steering. Advances in Experimental Medicine and Biology. Springer New York. https://doi.org/10.1007/978-0-387-70956-7_5
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