18F-FDG PET/CT in pure testicular Yolk Sac Tumor in adult

Abstract

We report a 35-year-old-male orchidecto- mized because of a painless left testicular mass. Reactive left inguinal lymphadenopathies were visualized by post-operative ultrasound while findings compatible with orchiepididymitis with necrosis, testicular abscess or underlying neoformation process were found by contrast-enhanced CT. The pathological diagnosis of the surgical piece allowed the diagnosis of pure testicular yolk sac tumor (YST). While YST is a part of mixed non- -seminomatous germ neoplasms in up to 79% of cases in the post-pubertal age (1), the pure form observed in this case is referred in only 2.4% of adult patients (2). YST usually behaves as a less aggressive tumor than embryonic carcinoma, so the diagnosis of extensively advanced disease is extremely rare therefore (1). Metastasis usually occurs only through lymphatic spread in adults as opposed to lymphatic and hematogenous spread in prepubescent patients. Serum markers and 18F- -FDG PET/CT may assist with the achievement of a differential diagnosis and provide an indicator of patient prognosis in this context. Serum AFP was 5200ng/mL. Additionally, the postoperative 18F-FDG PET/CT scan revealed extensive dissemination with high metabolic-rate (Figure 1, upper panel). Postoperative chemotherapy with three to four cycles of PEB (cisplatin, etoposide and bleomycin) regimen offers a chance for cure in extensively advanced patients (3). In our case, post-treatment 18F-FDG PET/CT revealed an almost complete metabolic remission after four cycles (Figure 1, lower panel). Diagnosis of pure YST, post-pubertal type, should be made only after meticulous microscopic examination rules out other germ cell components (3). In our case, pathological results (Figure 2) revealed a large neoplasm with extensive areas of necrosis that completely affected the testicle, the epididymis, and the spermatic cord, with involvement of surgical resection edges. The typical perivascular pattern with the characteristic Schiller-Duval bodies was predominantly observed in the conserved areas (Figure 2A). These Schiller-Duval bodies are a hallmark of YST seen in 50%-75% of cases (3). YST that present with only one histological pattern are extremely rare (3).