Are specific buffer effects the new frontier of Hofmeister phenomena? Insights from lysozyme adsorption on ordered mesoporous silica

Abstract

Lysozyme adsorption on mesoporous silica at pH 7.15 is buffer specific. The synergistic action of buffers and salts induces relevant effects on the charged interfaces, and thus on lysozyme loading. These findings, rising doubts on the validity of the Henderson-Hasselbalch equation, suggest the occurrence of Hofmeister phenomena also for buffers.