Hydrotropic nanocarriers for poorly soluble drugs

Abstract

Delivery of poorly water-soluble drugs remains as one of the most difficult challenges in the pharmaceutics and drug delivery areas. One of the recent approaches of increasing the water-solubility of poorly soluble drugs has been to utilize polymeric hydrotropic agents. Hydrotropic agents in nanocarrier forms, such as dendrimers and polymer micelles, increase the water solubility by orders of magnitude. The hydrotropic nanocarriers have advantages over other carriers for their high drug loading efficiency and long-term stability.