Eremophilane sesquiterpenes from Hawaiian endophytic fungus Chaetoconis sp. FT087

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Abstract

Seven sesquiterpene derivatives, including chaetopenoids A-F and dendryphiellin A1, and 6-methyl-(2E, 4E, 6S) octadienoic acid were isolated from the culture broth of Chaetoconis sp. FT087. Their structures were determined through the analysis of HRMS and NMR spectroscopic data. The absolute configurations of chaetopenoids A-D were elucidated by comparison of their CD and optical rotation data with those in the literature. Chaetopenoids A-C and E belong to the eremophilane type of sesquiterpenoids, while chaetopenoids D and F and dendryphiellin A1 have a trinor-eremophilane skeleton. All compounds were tested against A2780 and cisplatin resistant A2780CisR cell lines, and dendryphiellin A1 was moderately active with IC50 values of 6.6 and 9.1 μg/mL, respectively.

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Li, C. S., Ding, Y., Yang, B. J., Hoffman, N., Yin, H. Q., Mahmud, T., … Cao, S. (2016). Eremophilane sesquiterpenes from Hawaiian endophytic fungus Chaetoconis sp. FT087. Phytochemistry, 126, 41–46. https://doi.org/10.1016/j.phytochem.2016.03.005

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