Different astrocytic activation between adult Gekko japonicus and rats during wound healing in vitro

13Citations
Citations of this article
10Readers
Mendeley users who have this article in their library.

Abstract

Glial scar formation is a major obstacle to regeneration after spinal cord injury. Moreover, it has been shown that the astrocytic response to injury differs between species. Gekko japonicas is a type of reptile and it shows differential glial activation compared to that of rats. The purpose of the present study was to compare the proliferation and migration of astrocytes in the spinal cords of geckos and rats after injury in vitro. Spinal cord homogenate stimulation and scratch wound models were used to induce astrocytic activation in adult and embryonic rats, as well as in adult geckos. Our results indicated that astrocytes from the adult rat were likely activated by mechanical stimulation, even though they showed lower proliferation abilities than the astrocytes from the gecko under normal conditions. Furthermore, a transcriptome analysis revealed that the differentially expressed genes in astrocytes from adult rats and those from geckos were enriched in pathways involved in proliferation and the response to stimuli. This implies that intrinsic discrepancies in gene expression patterns might contribute to the differential activation of astrocytes between species.

References Powered by Scopus

Gene ontology: Tool for the unification of biology

32182Citations
N/AReaders
Get full text

Mapping and quantifying mammalian transcriptomes by RNA-Seq

10998Citations
N/AReaders
Get full text

KEGG for integration and interpretation of large-scale molecular data sets

3870Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Neuronal regeneration: Vertebrates comparative overview and new perspectives for neurodegenerative diseases

29Citations
N/AReaders
Get full text

Increased expression of ApoA1 after neuronal injury may be beneficial for healing

18Citations
N/AReaders
Get full text

Evolution of astrocytes: From invertebrates to vertebrates

16Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Gu, Y., Yang, J., Chen, H., Li, J., Xu, M., Hua, J., … Liu, M. (2015). Different astrocytic activation between adult Gekko japonicus and rats during wound healing in vitro. PLoS ONE, 10(5). https://doi.org/10.1371/journal.pone.0127663

Readers' Seniority

Tooltip

Researcher 3

60%

Professor / Associate Prof. 1

20%

PhD / Post grad / Masters / Doc 1

20%

Readers' Discipline

Tooltip

Agricultural and Biological Sciences 4

57%

Physics and Astronomy 1

14%

Neuroscience 1

14%

Engineering 1

14%

Article Metrics

Tooltip
Mentions
News Mentions: 1

Save time finding and organizing research with Mendeley

Sign up for free