Background: The present work was designed to evaluate the antibacterial properties of the methanol extracts of eleven selected Cameroonian spices on multi-drug resistant bacteria (MDR), and their ability to potentiate the effect of some common antibiotics used in therapy. Results: The extract of Cinnamomum zeylanicum against Escherichia coli ATCC 8739 and AG100 strains showed the best activities, with the lowest minimal inhibitory concentration (MIC) of 64 μg/ml. The extract of Dorstenia psilurus was the most active when tested in the presence of an efflux pump inhibitor, phenylalanine Arginine-β- Naphtylamide (PAβN), a synergistic effect being observed in 56.25 % of the tested bacteria when it was combined with Erythromycin (ERY). Conclusion: The present work evidently provides information on the role of some Cameroonian spices in the fight against multi-resistant bacteria. © 2012 Voukeng et al.; licensee BioMed Central Ltd.
CITATION STYLE
Voukeng, I. K., Kuete, V., Dzoyem, J. P., Fankam, A. G., Noumedem, J. A. K., Kuiate, J. R., & Pages, J. M. (2012). Antibacterial and antibiotic-potentiation activities of the methanol extract of some cameroonian spices against Gram-negative multi-drug resistant phenotypes. BMC Research Notes, 5. https://doi.org/10.1186/1756-0500-5-299
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