Ecology of Borrelia burgdorferi sensu lato in Europe: Transmission dynamics in multi-host systems, influence of molecular processes and effects of climate change

Abstract

The analysis of different multi-host systems suggests that even hosts that are not capable of transmitting Borrelia burgdorferi sensu lato (s.l.) to the tick vector, Ixodes ricinus, or that are secondary reservoirs for these agents contribute to the intensity of transmission and to the overall risk of Lyme borreliosis, through the process of vector augmentation and pathogen amplification. On the other hand, above certain threshold densities, or in the presence of competition with primary reservoir hosts or low attachment rate of ticks to reservoir hosts, incompetent or less competent hosts may reduce transmission through dilution. The transmission of B. burgdorferi s.l. is affected by molecular processes at the tick-host interface including mechanisms for the protection of spirochaetes against the host's immune response. Molecular biology also increasingly provides important identification tools for the study of tick-borne disease agents. Ixodes ricinus and B. burgdorferi s.l. are expanding their geographical range to northern latitudes and to higher altitudes through the effects of climate change on host populations and on tick development, survival and seasonal activity. The integration of quantitative ecology with molecular methodology is central to a better understanding of the factors that determine the main components of Lyme borreliosis eco-epidemiology and should result in more accurate predictions of the effects of climate change on the circulation of pathogens in nature. The analysis of the transmission dynamics of Borrelia burgdorferi sensu lato in multihost systems highlights the complex balance between dilution and vector (Ixodes ricinus) augmentation by vertebrates acting as secondary and incompetent reservoir hosts. The transmission of B. burgdorferi sl is affected by molecular processes at the tickhost interface and by mechanisms for the protection of spirochetes against the host's immune response. Ixodes ricinus and B. burgdorferi sl are expanding their geographic range to northern latitudes and to higher altitudes through effects of climate change on host populations, as well as on tick development, survival, and seasonal activity. © 2011 Federation of European Microbiological Societies.