The Cyclooxygenase enzymes (COX-1 and COX-2) incorporate 2 molecules of O2 into arachidonic acid (AA), resulting in an array of bioactive prostaglandins. However, much work has been done showing that COX-2 will perform this reaction on several different AA-containing molecules, most importantly, the endocannabinoid 2-arachidonoylglycerol (2-AG). The products of 2-AG oxygenation, prostaglandin glycerol esters (PG-Gs), are analogous to canonical prostaglandins. This chapter reviews the literature detailing the production, metabolism, and bioactivity of these compounds, as well as their detection in intact animals.
CITATION STYLE
Kingsley, P. J., Rouzer, C. A., Morgan, A. J., Patel, S., & Marnett, L. J. (2019). Aspects of Prostaglandin Glycerol Ester Biology. In Advances in Experimental Medicine and Biology (Vol. 1161, pp. 77–88). Springer New York LLC. https://doi.org/10.1007/978-3-030-21735-8_8
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