Galectin-3 as a regulator of the epithelial junction: Implications to wound repair and cancer

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Abstract

Epithelial cells are closely connected to each other and to the extracellular matrix by a set of adhesive contacts that provide tissues with unique barrier properties and play a prominent role in cell morphology, tissue physiology, and cell signaling. This review highlights advances made in understanding the contributions of galectin-3, a carbohydrate-binding protein with affinity toward β-galactosides, as a modulator of epithelial junction assembly and function. The interactions of galectin-3 within adhesive structures are discussed in relation to wound healing and tumor progression.

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Argüeso, P., Mauris, J., & Uchino, Y. (2015). Galectin-3 as a regulator of the epithelial junction: Implications to wound repair and cancer. Tissue Barriers, 3(3), 1–6. https://doi.org/10.1080/21688370.2015.1026505

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