Primary sclerosing cholangitis

Abstract

Primary sclerosing cholangitis (PSC) is an inflammatory disease of the bile duct system that is mainly associated with ulcerative colitis and Crohn’s disease. PSC may be complicated by progressive cholestasis, cirrhosis and liver failure. So far, there is no cure of the disease and medical treatment may alter the course of the disease without significant improvement of prognosis. In selected patients with a dominant stricture of the CBD or any of the hepatic ducts, endoscopic dilation may significantly reduce jaundice and ameliorate pruritus. A major concern is the occurrence of cholangiocarcinoma in PSC. Brush cytology and/or cholangioscopy with targeted biopsies may contribute to early detection of malignant lesions.