Polycystic Ovary Syndrome and Inflammation

Abstract

The polycystic ovary syndrome (PCOS) is the most prevalent female endocrine disorder in which hyperandrogenism is the main clinical feature. These steroids contribute to excessive weight gain, insulin resistance, hirsutism, acne, and androgenic alopecia. Visceral fat hypertrophy and androgen excess correlates with the degree of insulin resistance, the worse PCOS phenotype, and cardiovascular risk factors. Abnormal secretion of many adipocyte-derived products will produce a state of chronic low-intensity inflammation that progressively affects every organ and system. Appropriate nutrition, physical activity, and exercise may improve body composition, and metabolic and endocrine functioning. Different supplements (minerals, vitamins, and probiotics) may also contribute to neutralize the evolution of the syndrome.