The theory of path analysis is extended by considering a multivariate system of correlations from a dual perspective. Intrinsic factors exert a unidirectional influence on both the variance and covariance of dependent factors. In contrast, extrinsic factors have a bidirectional influence on the covariance structure of both antecedent and dependent factors and do not influence intrinsic variability. The mathematical model assumes a formally complete linear system of unitary factors. A coefficient is defined to quantify the influence of adventitious associations and is called a copath. Copaths are compared to path coefficients and to correlations due to common antecedents. The chain properties of these coefficients are derived along with a general formula and computational algorithm. The method is illustrated for multifactorial inheritance in extended pedigrees in the presence of different types of assortative mating. © 1980, Cambridge University Press. All rights reserved.
CITATION STYLE
Cloninger, C. R. (1980). Interpretation of intrinsic and extrinsic structural relations by path analysis: Theory and applications to assortative mating. Genetical Research, 36(2), 133–145. https://doi.org/10.1017/S0016672300019765
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