Background: Serologic testing algorithms for recent HIV seroconversion (STARHS) provide important information for HIV surveillance. We have previously demonstrated that a patient's antibody reaction pattern in a confirmatory line immunoassay (INNO-LIA™ HIV I/II Score) provides information on the duration of infection, which is unaffected by clinical, immunological and viral variables. In this report we have set out to determine the diagnostic performance of Inno-Lia algorithms for identifying incident infections in patients with known duration of infection and evaluated the algorithms in annual cohorts of HIV notifications.Methods: Diagnostic sensitivity was determined in 527 treatment-naive patients infected for up to 12 months. Specificity was determined in 740 patients infected for longer than 12 months. Plasma was tested by Inno-Lia and classified as either incident (
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Schüpbach, J., Bisset, L. R., Gebhardt, M. D., Regenass, S., Bürgisser, P., Gorgievski, M., … Günthard, H. F. (2012). Diagnostic performance of line-immunoassay based algorithms for incident HIV-1 infection. BMC Infectious Diseases, 12. https://doi.org/10.1186/1471-2334-12-88
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