Phase separation of BuGZ promotes Aurora A activation and spindle assembly

Abstract

The spindle matrix has been proposed to facilitate mitotic spindle assembly. In this issue, Huang et al. (2018. J. Cell Biol. https ://doi .org /10 .1083 /jcb .201706103) show that the spindle matrix protein BuGZ is sufficient to form micron-scale compartments that recruit and activate Aurora A, a critical kinase for spindle assembly.