Antihypertensive effect of isradipine on blood pressure at rest and during exercise

Abstract

After three months of treatment with isradipine, 20 patients with mild hypertension had reduced their resting blood pressure (BP) from 157/103 to 132/85 mm Hg and their BP during isometric exer­cise from 192/124 to 166/105 mm Hg. The isradipine dose necessary to normalize BP (both at rest and post-exercise) was 1.25 mg twice daily (2 X V2 tablet) in 50% of patients and 2.5 mg twice daily (2X1 tablet) in 25%. In the remaining 25% of patients, isradipine was combined with 1 mg/day bopindolol. There were virtually no ac­companying side effects; in particular, reflex tachy­cardia was negligible or absent. It is concluded that isradipine is a reliable anti­hypertensive treatment in mild-to-moderate hyper­tension. Am J Hypertens 1991;4:144S-146S. © 1991 by the American Journal of Hypertension, Ltd.