Organoiodine(III) mediated synthesis of novel symmetrical Bis([1,2,4]triazolo)[3,4-a:4',3'-c]phthalazines as antibacterial and antifungal agents

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Abstract

A series of new symmetrical 3,6-bis(aryl)bis([1,2,4]triazolo)[3,4-a:4',3'- c]phthalazines 9a-l has been conveniently synthesized by oxidative cyclization of 1,4-bis(substituted benzalhydrazino)phthalazines 8a-l promoted by iodobenzene diacetate under mild conditions (12 examples, up to 93% yield). All the 12 compounds were tested in vitro for their antibacterial activity against two Gram-positive bacteria, namely, Staphylococcus aureus, Bacillus subtilis and two Gram-negative bacteria, namely, Escherichia coli and Pseudomonas aeruginosa. All the synthesized compounds were also tested for their antifungal action against two fungi, Aspergillus niger and Aspergillus flavus. © 2012 HeteroCorporation.

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Prakash, O., Aneja, D. K., Hussain, K., Kumar, R., Arora, S., Sharma, C., & Aneja, K. R. (2012). Organoiodine(III) mediated synthesis of novel symmetrical Bis([1,2,4]triazolo)[3,4-a:4’,3’-c]phthalazines as antibacterial and antifungal agents. Journal of Heterocyclic Chemistry, 49(5), 1091–1097. https://doi.org/10.1002/jhet.943

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