Capturing the essence of folding and functions of biomolecules using coarse-grained models

197Citations
Citations of this article
177Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

The distances over which biological molecules and their complexes can function range from a few nanometres, in the case of folded structures, to millimetres, for example, during chromosome organization. Describing phenomena that cover such diverse length, and also time, scales requires models that capture the underlying physics for the particular length scale of interest. Theoretical ideas, in particular, concepts from polymer physics, have guided the development of coarse-grained models to study folding of DNA, RNA and proteins. More recently, such models and their variants have been applied to the functions of biological nanomachines. Simulations using coarse-grained models are now poised to address a wide range of problems in biology. © 2011 Macmillan Publishers Limited. All rights reserved.

Cite

CITATION STYLE

APA

Hyeon, C., & Thirumalai, D. (2011). Capturing the essence of folding and functions of biomolecules using coarse-grained models. Nature Communications. https://doi.org/10.1038/ncomms1481

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free