Pathophysiological aspects of neuro-endocrine regulation system in patients with obstructive sleep apnea syndrome

Abstract

Objective. To reveal the changes in the pituitary-thyroid, pituitary-gonadal, adrenal components and in the prolactinergic system of neuroendocrine regulation in patients with severe obstructive sleep apnea syndrome (OSAS). Material and methods. The study involved 51 men aged 46—55 years. The main group (BG) included 37 patients with severe OSAS. The duration of clinical manifestations of OSAS was 10.5±1.5 years. OSAS was verified on the basis of clinical and functional studies and polysomnographic monitoring in accordance with the AASM criteria (2014). The control group (CG) consisted of 14 age-matched men without sleep-disordered breathing. The body mass index in BG was 34.2±1.8 compared to 28.2±2.1 kg/m2 in CG. Serum concentrations of thyroid-stimulating hormone (TTG), free thyroxine (T4), triiodothyronine (T3), cortisol, prolactin, testosterone, luteonizing (LH) and follicle-stimulating (FSH) hormones were determined by the immunoradiological method using the standard DIA test system (Russia) and the analyzer «Immunotest-800». Results. Patients with severe OSAS had decreased concentration of free thyroxine (T4) and decreased activity of thyroid stimulating hormone (TSH) (р<0.001), increased concentration of prolactin and cortisol (р<0.001), decreased concentration of luteinizing hormone (LH), follicle-stimulating hormone (FSH) and testosterone compared to the controls (р<0.001). Сonclusion. The changes in the hypothalamic-pituitary-gonadal system are a manifestation of disturbances of the mechanisms of self-regulation and compensation that indicates the presence of maladaptive reactions of the neuroendocrine system.