Treatment of suspected hyper-reactive malarial splenomegaly (HMS) in pregnancy with mefloquine

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Abstract

Malaria infections in pregnancy are associated with adverse outcomes for both mother and child. There are few data on hyper-reactive malarial splenomegaly, an aberrant immunological response to chronic or recurrent malaria in pregnancy. This retrospective assessment reviewed the impact of mefloquine treatment on pregnant women with suspected hyper-reactive malarial splenomegaly in an area of low malaria transmission in the 1990s, showing significant reductions in spleen size and anemia and anti-malarial antibody titers without any notable negative effect on treated women or their newborns. Copyright © 2014 by The American Society of Tropical Medicine and Hygiene.

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Jaroensuk, J., Stoesser, N., Leimanis, M. L., Jittamala, P., White, N. J., Nosten, F. H., & McGready, R. (2014). Treatment of suspected hyper-reactive malarial splenomegaly (HMS) in pregnancy with mefloquine. American Journal of Tropical Medicine and Hygiene, 90(4), 609–611. https://doi.org/10.4269/ajtmh.13-0706

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