miR-23a/b-3p promotes hepatic lipid accumulation by regulating Srebp-1c and Fas

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Abstract

miR-23a-3p and miR-23b-3p are members of the miR-23~27~24-2 superfamily. The role of miR-23a/b-3p in regulating hepatic lipid accumulation is still unknown. Here, we found that increased miR-23a-3p and miR-23b-3p levels were accompanied by an increase in the protein levels of the sterol regulatory element-binding protein-1 (SREBP-1) and fatty acid synthase (FAS) in the steatotic livers of mice fed a high-fat diet and leptin receptor-deficient type 2 diabetic mice (db/db). Importantly, overexpression of miR-23a/b-3p in Hep1-6 cells elevated the intracellular triglyceride level and upregulated the expression of Srebp-1c and Fas. Taken together, these results suggested that miR-23a/b-3p enhanced mRNA stability by binding the 5'-UTR of Srebp-1c and Fas mRNA, thereby promoting triglyceride accumulation in hepatocytes.

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Li, L., Zhang, X., Ren, H., Huang, X., Shen, T., Tang, W., … Li, J. (2022). miR-23a/b-3p promotes hepatic lipid accumulation by regulating Srebp-1c and Fas. Journal of Molecular Endocrinology, 68(1), 35–49. https://doi.org/10.1530/JME-20-0324

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