Skip to main content
Journal ArticleOPEN ACCESS

The Med1 subunit of the mediator complex induces liver cell proliferation and is phosphorylated by AMP kinase

Journal of Biological Chemistry (2013) 288(39) 27898-27911
DOI: 10.1074/jbc.M113.486696
20Citations
Citations of this article
27Readers
Mendeley users who have this article in their library.

Abstract

Background: The Med1 subunit of the Mediator complex orchestrates metabolic pathways of energy metabolism. Results: Overexpression of Med1 in liver enhances hepatocyte proliferation and the cellular energy sensor AMPK phosphorylates Med1. Conclusion: Med1 is essential for hepatocellular proliferation and energy homeostasis downstream to AMPK. Significance: Med1 and its phosphorylation by AMPK may have important implications in the pathophysiology of liver. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.

References Powered by Scopus

Role of AMP-activated protein kinase in mechanism of metformin action

Journal of Clinical Investigation
4821Citations
N/AReaders
Get full text

AMPK: A nutrient and energy sensor that maintains energy homeostasis

Nature Reviews Molecular Cell Biology
3524Citations
N/AReaders
Get full text

TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival

Cell
3280Citations
N/AReaders
Get full text
View more at Scopus

Cited by Powered by Scopus

Tumour microenvironment and metabolic plasticity in cancer and cancer stem cells: Perspectives on metabolic and immune regulatory signatures in chemoresistant ovarian cancer stem cells

Seminars in Cancer Biology
125Citations
N/AReaders
Get full text

PPARα-deficient ob/ob obese mice become more obese and manifest severe hepatic steatosis due to decreased fatty acid oxidation

American Journal of Pathology
67Citations
N/AReaders
Get full text

Chromatin recruitment of activated AMPK drives fasting response genes co-controlled by GR and PPARα

Nucleic Acids Research
45Citations
N/AReaders
Get full text
View more at Scopus

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Viswakarma, N., Jia, Y., Bai, L., Gao, Q., Lin, B., Zhang, X., … Reddy, J. K. (2013). The Med1 subunit of the mediator complex induces liver cell proliferation and is phosphorylated by AMP kinase. Journal of Biological Chemistry, 288(39), 27898–27911. https://doi.org/10.1074/jbc.M113.486696

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 7

44%

Researcher 6

38%

Professor / Associate Prof. 3

19%

Readers' Discipline

Tooltip

Agricultural and Biological Sciences 10

63%

Biochemistry, Genetics and Molecular Bi... 3

19%

Medicine and Dentistry 2

13%

Pharmacology, Toxicology and Pharmaceut... 1

6%

Save time finding and organizing research with Mendeley

Sign up for free