NIOSOMES:THE UNIQUE VESICULAR DRUG CARRIERS

Abstract

A review. Drug targeting is the ability to direct a therapeutic agent specifically to desired site of action with little or no interaction with nontarget tissue. Niosomes are one of the best carriers for drug targeting. Niosomes are self-assembled vesicles composed primarily of synthetic surfactants and cholesterol. They are analogous in structure to the more widely studied liposomes formed from biol. derived phospholipids. Niosomes are biodegradable, relatively nontoxic, more stable and inexpensive, an alternative to liposomes. The method of preparation of niosome is based on liposome technol. The basic process of preparation is the same i.e. hydration by aqueous phase of the lipid phase which may be either a pure surfactant or a mixture of surfactant with cholesterol. After preparing niosomal dispersion, unentrapped drug is separated by dialysis centrifugation or gel filtration. Niosomes can be SUV (Small Unilamellar Vesicles), MLV (Multilamellr Vesicles) or LUV (Large Unilamellar Vesicles). Niosomal drug delivery is potentially applicable to many pharmacol. agents for their action against various diseases.