The RUNX family of transcription factors plays important roles in tissue-specific gene expression. Many of their functions depend on specific post-translational modifications (PTMs), and in this review, we describe how PTMs govern RUNX DNA binding, transcriptional activity, protein stability, cellular localization, and protein-protein interactions. We also report how these processes can be disrupted in disease settings. Finally, we describe how alterations of RUNX1, or the enzymes that catalyze its post-translational modifications, contribute to hematopoietic malignancies.
CITATION STYLE
Blumenthal, E., Greenblatt, S., Huang, G., Ando, K., Xu, Y., & Nimer, S. D. (2017). Covalent modifications of RUNX proteins: Structure affects function. In Advances in Experimental Medicine and Biology (Vol. 962, pp. 33–44). Springer New York LLC. https://doi.org/10.1007/978-981-10-3233-2_3
Mendeley helps you to discover research relevant for your work.