Role of reactive oxygen species during hypertension in response to chronic antiangiogenic factor (sFlt-1) excess in pregnant rats

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Abstract

Background Preeclampsia is associated with increased levels of reactive oxygen species (ROS) and the antiangiogenic factor, soluble fms-like tyrosine kinase-1 (sFlt-1). Moreover, recent studies have indicated that chronic sFlt-1 excess causes hypertension in pregnant animals. The purpose of this study was to evaluate the role of ROS in mediating sFlt-1-induced hypertension in the pregnant rat. Methods Mean arterial pressure (MAP), and plasma sFlt-1 and tissue ROS levels were measured in the following groups: (i) pregnant controls; (ii) sFlt-1-treated pregnant rats; (iii) Tempol-treated pregnant rats; (iv) sFlt-1- and Tempol-treated pregnant rats. Results MAP increased from 104 2mmHg in pregnant control rats to 118 3mmHg (P =0.002) in sFlt-1-infused rats. Basal and nicotinamide adenine dinucleotide phosphate (NADPH)-stimulated levels of tissue ROS were increased in response to excess sFlt-1 during pregnancy. Pretreatment with Tempol attenuated oxidative stress and hypertension in response to sFlt-1. Conclusions ROS play an important role in mediating hypertension in response to chronic sFlt-1 excess during pregnancy. © 2011 American Journal of Hypertension, Ltd.

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Tam Tam, K. B., Lamarca, B., Arany, M., Cockrell, K., Fournier, L., Murphy, S., … Granger, J. P. (2011). Role of reactive oxygen species during hypertension in response to chronic antiangiogenic factor (sFlt-1) excess in pregnant rats. American Journal of Hypertension, 24(1), 110–113. https://doi.org/10.1038/ajh.2010.180

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