A novel near-infrared fluorescent light-up probe with a tumor-homing pentapeptide, CREKA (Cys-Arg-Glu-Lys-Ala), specifically binds to fibrin-fibronectin complexes was rationally designed and developed for biomedical imaging. Its superior practical applications in tumor imaging and drug-induced liver injury detection are well demonstrated for the first time.
Zeng, X., Chen, Z., Tang, L., Yang, H., Liu, N., Zhou, H., … Xiao, Y. (2019). A novel near-infrared fluorescent light-up probe for tumor imaging and drug-induced liver injury detection. Chemical Communications, 55(17), 2541–2544. https://doi.org/10.1039/c8cc10286d