The biological activity of four pillarplex compounds featuring different metals and anions was investigated. The toxicity of the compounds against four bacterial strains [Bacillus subtilis (ATCC6633), Staphylococcus aureus (ATCC6538), Escherichia coli (UVI isolate), Pseudomonas aeruginosa], one fungus (Candida albicans), and a human cell line (HepG2) was determined. Additionally, a UV-Vis titration study of the pillarplexes was carried out to check for stability depending on pH- and chloride concentration changes and evaluate the applicability in physiological media. All compounds are bioactive: the silver compounds showed higher activity against bacteria and fungi, and the corresponding gold pillarplexes were less toxic against human cells.
CITATION STYLE
Pöthig, A., Ahmed, S., Winther-Larsen, H. C., Guan, S., Altmann, P. J., Kudermann, J., … Åstrand, O. A. H. (2018). Antimicrobial activity and cytotoxicity of Ag(I) and Au(I) pillarplexes. Frontiers in Chemistry, 6(NOV). https://doi.org/10.3389/fchem.2018.00584
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