Serum Levels of Insulin Like Growth Factor-1(IGF-1) in Patients with Seborrheic Dermatitis

Abstract

Seborrheic dermatitis (SD) is a chronic inflammatory skin disease affecting sebaceous areas of the face, scalp, upper chest and back .Five factore are believed to play a key role in the development of SD lesions: excess sebum production, malassezia colonies over areas covered with lipids, lipase secreted by malassezia, release of inflammatory cytokines into the skin, keratinocyte proliferation and differentiation. Evaluation of serum levels of Insulin Like Growth Factor-1(IGF-1) in seborrheic dermatitis patients. Serum IGF-1 concentrations were measured in 50 patients with SD and 30 healthy controls using enzyme-linked immunosorbent assay (ELISA). Serum levels of IGF-1 in patients with SD were found to be higher than in healthy controls (P =0.045). Increased serum IGF-1 levels probably reflect the role of IGF-1 in the pathogenesis of SD.