Y-Box-Binding Protein-1: A Promising Therapeutic Target for Cancer

Abstract

Various reports have proved that Y-box-binding protein-1 (YB-1) is a protein with multiple roles including transcription/translation regulation of several proteins taking part in stemness. It plays an essential role in embryogenesis but gets remarkably reduced or completely shut down in adult stage. In many cancers, YB-1 has been reported to be reexpressed and a high nuclear translocation of YB-1 is linked with drug resistance and cancer relapse. In this chapter, we have discussed about YB-1 and DNA/RNA interaction, mechanism of YB-1 translocation, and therapeutic importance of YB-1 in several cancer signaling pathways. YB-1-based immunotherapy and YB-1-dependent virotherapy are discussed in detail. Overall, this book chapter supports the potential of YB-1 as a therapeutic target and emphasizes the significance of developing YB-1-specific inhibitors in cancer.