Synthesis and anti-inflammatory activity of new thiazolidine-2,4-diones, 4-thioxothiazolidinones and 2-thioxoimidazolidinones

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Abstract

New benzylidene imidazolidine and thiazolidine derivatives were prepared by nucleophilic addition on cyanoacrylates from substituted thioxoimidazolidinones, thiazolidinediones and thioxothiazolidinones. Anti-inflammatory activity of the synthesized thiazolidines was evaluated by the carrageenin-induced paw oedema test.

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Santos, L. C., Uchôa, F. T., Cañas, A. R. P. A., Sousa, I. A., Moura, R. O., Lima, M. C. A., … Barbe, J. (2005). Synthesis and anti-inflammatory activity of new thiazolidine-2,4-diones, 4-thioxothiazolidinones and 2-thioxoimidazolidinones. Heterocyclic Communications, 11(2), 121–128. https://doi.org/10.1515/HC.2005.11.2.121

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