Tetracyclines for treating multidrug-resistant Acinetobacter baumannii ventilator-associated pneumonia

Abstract

Objective: To report the use of tetracyclines for the treatment of multidrug-resistant Acinetobacter baumannii ventilator-associated pneumonia (VAP). Design: Observational case series. Setting: The Presley Regional Trauma Center located within the Regional Medical Center, Memphis, Tennessee, USA. Patients and participants: Seven critically ill trauma patients with VAP caused by A. baumannii isolates that were resistant to all antibiotics tested except for doxycycline or minocycline. Interventions: Patients were treated with IV doxycycline or minocycline for an average of 13.5 (range 9-20) days. Measurements and results: Doxycycline or minocycline was successful in six of seven patients. Conclusions: Doxycycline or minocycline may be effective for treating multidrug-resistant A. baumannii VAP.