Experiments on computer assisted optimization of the Escherichia coli fermentation process using optferm

Abstract

We used the software Optferm to model and optimize the bioprocess of escherichia coli fermentation, simulating the conditions of a fed-batch bioreactor. The results, obtained by employing different AI approaches, provided useful orientation for nutrient feed strategies for increased productivity. In conclusion, we believe in silico tools can perform a rapid and valid optimization of bioprocesses avoiding expensive experiments. © 2011 Springer-Verlag Berlin Heidelberg.