Naive T cells have long been regarded as a developmentally synchronized and fairly homogeneous and quiescent cell population, the size of which depends on age, thymic output and prior infections. However, there is increasing evidence that naive T cells are heterogeneous in phenotype, function, dynamics and differentiation status. Current strategies to identify naive T cells should be adjusted to take this heterogeneity into account. Here, we provide an integrated, revised view of the naive T cell compartment and discuss its implications for healthy ageing, neonatal immunity and T cell reconstitution following haematopoietic stem cell transplantation.
CITATION STYLE
Van Den Broek, T., Borghans, J. A. M., & Van Wijk, F. (2018, June 1). The full spectrum of human naive T cells. Nature Reviews Immunology. Nature Publishing Group. https://doi.org/10.1038/s41577-018-0001-y
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