Comparative study of microanastomosis with distinct 10-0 Nylon sutures in rats

Abstract

Objective: The aim of this study is to compare micro-sutures commonly used in our midst. Methods: In this double-blind study, 30 Wistar rats were operated randomly divided into three groups matched according to the suture used (Nylon 10-0, 75micron, brands Microsuture®, Polysuture® and Ethicon®). We analyzed the number of surgical nodes required, bleeding, surgical time and histological evaluation. Results: There was no significant difference between the amount of stitches of arterial suture per anastomosis. Surgical time was longer in Microsuture® group as compared to Polysuture ® (p = 0.05). Bleeding in Microsuture® group was higher when compared to the others (p < 0.01). In the histological analysis, the Microsuture® group showed a greater tendency to develop fibrosis and aneurysm in surgical site than the others (p < 0.01 and p=0,05, respectively). Similarly, the Ethicon ® group showed less tendency to myointimal proliferation than the rest. (p = 0.025). Conclusion: The results confirm the relevance of the choice of surgical thread as an independent determining factor for the success of the procedure, besides serving as a rational subsidy for a better cost-benefit analysis. Level of Evidence I, Experimental Study, Controlled Animal Study.