Effect of papulacandin B on β-glucan synthesis in Schizosaccharomyces pombe

63Citations
Citations of this article
9Readers
Mendeley users who have this article in their library.

Abstract

The antifungal antibiotic papulacandin β inhibited B(1,3)glucan-synthase activity, in vitro, from Schizosaccharomyces pombe. Levels of β(1,3)glucan-synthase from antibiotic-treated cultures were lower than the control cultures whereas mannan-synthase and β(1,3)glucanase activities were almost unaffected. The presence of an osmotic stabilizer reduced the inhibition of growth caused by the antibiotic. Addition of papulacandin β to a culture of S. pombe specifically inhibited incorporation of glucose into the β-glucan cell wall fraction. The fatty acids as well as the hydroxyl groups on the phenol residue of the papulacandin β molecule were essential for the inhibitory activity. © 1983.

References Powered by Scopus

Papulacandins, A New Family Of Antibiotics With Antifungal Activity: I. Fermentation, Isolation, Chemical And Biological Characterization Of Papulacandins A, B, C, D And E

150Citations
N/AReaders
Get full text

Studies On Aculeacin. I Isolation And Characterization Of Aculeacin A

122Citations
N/AReaders
Get full text

Papulacandin B: an Inhibitor of Glucan Synthesis in Yeast Spheroplasts

112Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Molecular basis of cell integrity and morphogenesis in Saccharomyces cerevisiae

422Citations
N/AReaders
Get full text

A Whole-Cell Candida albicans Assay for the Detection of Inhibitors towards Fungal Cell Wall Synthesis and Assembly

164Citations
N/AReaders
Get full text

Rho1 GTPase activates the (1-3)β-D-glucan synthase and is involved in Schizosaccharomyces pombe morphogenesis

152Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Varona, R., Pérez, P., & Durán, A. (1983). Effect of papulacandin B on β-glucan synthesis in Schizosaccharomyces pombe. FEMS Microbiology Letters, 20(2), 243–247. https://doi.org/10.1111/j.1574-6968.1983.tb00125.x

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 4

67%

Professor / Associate Prof. 1

17%

Researcher 1

17%

Readers' Discipline

Tooltip

Biochemistry, Genetics and Molecular Bi... 4

67%

Agricultural and Biological Sciences 1

17%

Pharmacology, Toxicology and Pharmaceut... 1

17%

Save time finding and organizing research with Mendeley

Sign up for free