The antifungal antibiotic papulacandin β inhibited B(1,3)glucan-synthase activity, in vitro, from Schizosaccharomyces pombe. Levels of β(1,3)glucan-synthase from antibiotic-treated cultures were lower than the control cultures whereas mannan-synthase and β(1,3)glucanase activities were almost unaffected. The presence of an osmotic stabilizer reduced the inhibition of growth caused by the antibiotic. Addition of papulacandin β to a culture of S. pombe specifically inhibited incorporation of glucose into the β-glucan cell wall fraction. The fatty acids as well as the hydroxyl groups on the phenol residue of the papulacandin β molecule were essential for the inhibitory activity. © 1983.
CITATION STYLE
Varona, R., Pérez, P., & Durán, A. (1983). Effect of papulacandin B on β-glucan synthesis in Schizosaccharomyces pombe. FEMS Microbiology Letters, 20(2), 243–247. https://doi.org/10.1111/j.1574-6968.1983.tb00125.x
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