Effect of papulacandin B on β-glucan synthesis in Schizosaccharomyces pombe

63Citations
Citations of this article
9Readers
Mendeley users who have this article in their library.

Abstract

The antifungal antibiotic papulacandin β inhibited B(1,3)glucan-synthase activity, in vitro, from Schizosaccharomyces pombe. Levels of β(1,3)glucan-synthase from antibiotic-treated cultures were lower than the control cultures whereas mannan-synthase and β(1,3)glucanase activities were almost unaffected. The presence of an osmotic stabilizer reduced the inhibition of growth caused by the antibiotic. Addition of papulacandin β to a culture of S. pombe specifically inhibited incorporation of glucose into the β-glucan cell wall fraction. The fatty acids as well as the hydroxyl groups on the phenol residue of the papulacandin β molecule were essential for the inhibitory activity. © 1983.

Cite

CITATION STYLE

APA

Varona, R., Pérez, P., & Durán, A. (1983). Effect of papulacandin B on β-glucan synthesis in Schizosaccharomyces pombe. FEMS Microbiology Letters, 20(2), 243–247. https://doi.org/10.1111/j.1574-6968.1983.tb00125.x

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free