Continuous infusion of amphotericin B deoxycholate in the treatment of cryptococcal meningoencephalitis: Analysis of safety and fungicidal activity

Abstract

We measured fungicidal activity of continuous infusion of amphotericin B deoxycholate plus 5′flucytosine using quantitative cultures of cerebrospinal fluid (CSF) obtained from lumbar punctures of human immunodeficiency virus (HIV)-infected patients with neurocryptococcosis during 14 days of treatment. Glomerular renal function was preserved in all patients. Mycological efficacy with progressive reduction in CSF cryptococcal colony-forming units was comparable to standard 4-h infusion of amphotericin B. © 2010 by the Infectious Diseases Society of America. All rights reserved.