Methods to Investigate the Role of β-Arrestin Signaling in Parkinson’s Disease

Abstract

β-Arrestin function has largely been investigated in cell culture-based systems. Here we describe methods to investigate β-arrestin2 signaling in vivo by developing novel mouse models and viral methods to overexpress β-arrestin2 in the mouse brain. The methods and concepts described here are in the context of Parkinson’s disease (PD) and developing automated in vivo drug screening platforms.