Animal models of Parkinson's disease are essential to explore pathophysiological hypotheses and to test new treatment options, including neurotrophic factors. Catecholaminergic neurotoxins used to generate such models are 6-hydroxydopamine and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. These neurotoxins predominantly kill dopaminergic neurons through oxidative damage and mitochondrial failure, although 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine fails to induce a significant dopaminergic neurodegeneration in rats. The present chapter describes a protocol for the 6-hydroxydopamine rat model based on stereotaxic injection performed only unilaterally, which mimics an early-to-mid stage of the disease. © 2012 Springer Science+Business Media, LLC.
CITATION STYLE
Mercanti, G., Bazzu, G., & Giusti, P. (2012). A 6-hydroxydopamine in vivo model of parkinson’s disease. Methods in Molecular Biology, 846, 355–364. https://doi.org/10.1007/978-1-61779-536-7_30
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