Aromatase inhibitors and anti-synthetase syndrome

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Abstract

Adjuvant therapy in postmenopausal women with endocrine-responsive breast cancer (BC) is actually centered on the use of anti-aromatase inhibitors (AI). Several reports, however, are emerging in literature associating the use of this drugs to rheumatic disorders. This case report describes the first case of anti-synthetase syndrome diagnosis after treatment with anti-estrogen agents in a patient with pre-existing rheumatoid arthritis.

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Mascella, F., Gianni, L., Affatato, A., & Fantini, M. (2016). Aromatase inhibitors and anti-synthetase syndrome. International Journal of Immunopathology and Pharmacology, 29(3), 494–497. https://doi.org/10.1177/0394632016651086

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