Antibacterial activity of linezolid against gram-negative bacteria: Utilization of ε-poly-l-lysine capped silica xerogel as an activating carrier

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Abstract

In recent times, many approaches have been developed against drug resistant Gram-negative bacteria. However, low-cost high effective materials which could broaden the spectrum of antibiotics are still needed. In this study, enhancement of linezolid spectrum, normally active against Gram-positive bacteria, was aimed for Gram-negative bacteria growth inhibition. For this purpose, a silica xerogel prepared from a low-cost precursor is used as a drug carrier owing to the advantages of its mesoporous structure, suitable pore and particle size and ultralow density. The silica xerogel is loaded with linezolid and capped with ε-poly-l-lysine. The developed nano-formulation shows a marked antibacterial activity against to Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus. In comparison to free linezolid and ε-poly-l-lysine, the material demonstrates a synergistic effect on killing for the three tested bacteria. The results show that silica xerogels can be used as a potential drug carrier and activity enhancer. This strategy could provide the improvement of antibacterial activity spectrum of antibacterial agents like linezolid and could represent a powerful alternative to overcome antibiotic resistance in a near future.

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Kaya, G. G., Medaglia, S., Candela-Noguera, V., Tormo-Mas, M. Á., Marcos, M. D., Aznar, E., … Martínez-Máñez, R. (2020). Antibacterial activity of linezolid against gram-negative bacteria: Utilization of ε-poly-l-lysine capped silica xerogel as an activating carrier. Pharmaceutics, 12(11), 1–14. https://doi.org/10.3390/pharmaceutics12111126

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